Diethylamine → Methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate

HRID 554006Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 554006
C(NCC)C.[CH3:6][O:7][C:8]([N:10]1[CH2:15][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=2)[N:13](C(OCC2C3C=CC=CC=3C3C2=CC=CC=3)=O)[CH:12]([CH:42]=[CH:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:11]1)=[O:9]>C(#N)C>[CH2:47]([O:46][C:44]([CH:43]=[CH:42][CH:12]1[NH:13][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=2)[CH2:15][N:10]([C:8]([O:7][CH3:6])=[O:9])[CH2:11]1)=[O:45])[CH3:48]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 67460768HCID 67460768, Verbindung

Produkt 1

HCID 67464101Methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Diethylamine (2 mL) was added to a solution of 2-(2-ethoxycarbonylvinyl)-6-(3,4,5-trifluorophenyl)piperazine-1,4-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 4-methyl ester (1.03 g) in acetonitrile (10 mL), and the reaction solution was stirred at room temperature for one hour. The reaction solution was concentrated, and the residue was purified by silica gel column chromatography (heptane->ethyl acetate) to obtain 422 mg of an E/Z isomer mixture of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. customthe residue was purified by silica gel column chromatography (heptane->ethyl acetate)
  3. customto obtain

Quellen und Nachweise

ORD-Eintrag
ord-0fe97f69f1be4f8493f5484152280e3d
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048878B2

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