C([N:8]1[CH2:16][CH:15]2[CH:10]([C:11]([CH3:19])([CH3:18])[CH2:12][CH2:13][C:14]2=[O:17])[CH2:9]1)C1C=CC=CC=1.[ClH:20]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:20].[CH3:18][C:11]1([CH3:19])[CH:10]2[CH:15]([CH2:16][NH:8][CH2:9]2)[C:14](=[O:17])[CH2:13][CH2:12]1A mixture of 2.31 g of (3aRS,7aRS)-2-benzyl-7,7-dimethyl-4-perhydroisoindolone and 9.96 cm3 of 1N hydrochloric acid in 25 cm3 of anhydrous ethanol is heated to 60° C. with stirring; 0.11 g of 20% palladium hydroxide on charcoal is added and the reaction mixture is then hydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure. After reaction for 6 hours, the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). 2.17 g of (3aRS,7aRS)-7,7-dimethyl-4-perhydroisoindolone hydrochloride are obtained, in the form of a pink oil containing ethanol.
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