Indole-3-Acetic Acid → (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindolol

HRID 55410

Reaktionsgleichung

Reaktionsgleichung von HRID 55410
Cl.[CH3:2][C:3]1([CH3:21])[CH:11]2[CH:7]([CH2:8][NH:9][CH2:10]2)[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])([OH:12])[CH2:5][CH2:4]1.[NH:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]([CH2:31][C:32](O)=[O:33])=[CH:23]1>>[CH3:2][C:3]1([CH3:21])[CH:11]2[CH:7]([CH2:8][N:9]([C:32](=[O:33])[CH2:31][C:24]3[C:25]4[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][CH:23]=3)[CH2:10]2)[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])([OH:12])[CH2:5][CH2:4]1

Komponenten

3

Edukt 2

HCID 802Indole-3-Acetic AcidHCID 67714309(3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-4-perhydroisoindolol hydrochloride

Produkt 1

HCID 67713946(3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindololAusbeute 20,4 %

Versuchsvorschrift

By working according to the experimental procedure of Example 6, from 0.6 g of (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-4-perhydroisoindolol hydrochloride and 0.4 g of 3-indoleacetic acid, and after purification on a column of silica gel (particle size 0.04-0.06 mm, diameter 2.4 cm, height 15 cm), 0.17 g of (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindolol is obtained, in the form of a white foam.

Aufarbeitung

  1. customafter purification on a column of silica gel (particle size 0.04-0.06 mm, diameter 2.4 cm, height 15 cm)

Quellen und Nachweise

ORD-Eintrag
ord-cf9e5536c08644c1bc1ee6e1672ec56c
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624950

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