2-Chloro-4-fluorobenzylamine → N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide

HRID 554110

Reaktionsgleichung

Reaktionsgleichung von HRID 554110
Cl[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:11](=[O:20])[C@@H:12]1[CH2:16][CH2:15][C:14](=[O:17])[N:13]1[CH2:18]C.CN1C(=O)CC[C@H]1C(O)=O.C(N1C(=O)CC[C@H]1C(O)=O)C.FC1C=CC(CN)=C([C:51]([F:54])([F:53])[F:52])C=1.ClC1C=C(F)C=CC=1CN>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:9][NH:10][C:11](=[O:20])[C@@H:12]2[CH2:16][CH2:15][C:14](=[O:17])[N:13]2[CH3:18])=[C:2]([C:51]([F:54])([F:53])[F:52])[CH:7]=1

Komponenten

6

Edukt 5

HCID 1399092-Chloro-4-fluorobenzylamineHCID 2734878(4-Fluoro-2-(trifluoromethyl)phenyl)methanamineHCID 18605196L-Proline, 1-ethyl-5-oxo-HCID 18649403(2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acidHCID 49864911N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide

Produkt 1

HCID 67458706N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide

Versuchsvorschrift

N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide (Example 70) but 1-methyl-5-oxoproline (prepared as describe below) was substituted for 1-ethyl-5-oxoproline and {[4-fluoro-2-(trifluoromethyl)phenyl]methyl}amine was substituted for 2-chloro-4-fluorobenzylamine.

Quellen und Nachweise

ORD-Eintrag
ord-c6c8234805c647959e5883507a9420bf
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048907B2

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