4-Fluorobenzenesulfonyl chloride → 1-[(4-Fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde

HRID 554181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 554181
FC(F)(F)C1C=CC=CC=1C1NC=C(C(OCC)=O)C=1.FC1C=CC(S(Cl)(=O)=O)=CC=1.[F:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([N:42]2[C:46]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=3[C:53]([F:56])([F:55])[F:54])=[CH:45][C:44]([C:57](OCC)=[O:58])=[CH:43]2)(=[O:41])=[O:40])=[CH:35][CH:34]=1>>[F:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([N:42]2[C:46]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=3[C:53]([F:54])([F:56])[F:55])=[CH:45][C:44]([CH:57]=[O:58])=[CH:43]2)(=[O:40])=[O:41])=[CH:35][CH:34]=1

Komponenten

4

Edukt 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 66924625HCID 66924625, VerbindungHCID 66924947ethyl 1-[(4-fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

Produkt 1

HCID 866207401-[(4-Fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde

Versuchsvorschrift

Using ethyl 5-(2-trifluoromethylphenyl)-1H-pyrrole-3-carboxylate and 4-fluorobenzenesulfonyl chloride, a procedure as in Reference Example 4 was performed to synthesize ethyl 1-[(4-fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate, and procedures as in Reference Examples 5 and 6 were sequentially performed to give the title compound as crystals.

Quellen und Nachweise

ORD-Eintrag
ord-8f26b5637283479385934efca045589f
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048909B2

Notizen zur Reaktion

Wird geladen…