HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanamine, hydrochloride (1:1) → N-Methyl-1-{4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 4-Methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620741 | — |
| Produkt | N-Methyl-1-{4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride | HCID 66924933 | 50,1% |
Reaktionsschritte
Using 4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde (310 mg), methylammonium chloride (617 mg) and sodium cyanoborohydride (172 mg), a procedure as in Example 4 was performed to give the title compound as colorless crystals (yield 179 mg, 50%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-b4e98dbc1dd046cbab5250eb05e3411a |
| Quellennotiz | uspto-grants-2011_11 |