HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 1-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 1-Butanesulfonyl chloride | HCID 75430 | — |
| Edukt | Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate | HCID 57522146 | — |
| Produkt | 1-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine | HCID 66924931 | 24% |
Reaktionsschritte
Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (70 mg), sodium hydride (60% in oil, 98 mg) and butane-1-sulfonyl chloride (230 mg), a procedure as in Example 38 was performed to give the title compound as pale-purplish red crystals (yield 18 mg, 21%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-eea15db9a3b84e109d374ed1e2ba4958 |
| Quellennotiz | uspto-grants-2011_11 |