1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → 1-[4-(8-Nitroquinolin-4-yloxy)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea

HRID 554481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 554481
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)([O-:3])=[O:2].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][C:24]=1[C:32]([F:35])([F:34])[F:33]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([Cl:22])=[C:24]([C:32]([F:34])([F:33])[F:35])[CH:25]=2)=[O:31])=[CH:17][CH:16]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 533302934-(8-Nitroquinolin-4-yloxy)phenylamine

Produkt 1

HCID 595094071-[4-(8-Nitroquinolin-4-yloxy)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)ureaAusbeute 88,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

4-(8-Nitroquinolin-4-yloxy)phenylamine (7.5 mg, 0.027 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isocyanate (11.8 mg, 0.054 mmol) were dissolved in tetrahydrofuran, and stirred at room temperature for 12 hours. When the reaction was completed, the solvent was removed by vacuum distillation, and a white solid product was filtered to obtain 12.0 mg of the desired compound (yield 88.9%).

Aufarbeitung

  1. customthe solvent was removed by vacuum distillation
  2. filtrationa white solid product was filtered

Quellen und Nachweise

ORD-Eintrag
ord-b00dce08f2a34107933f7e0c12cf30b4
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08049014B2

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