Hydrochloric Acid → (5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

HRID 554609Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 554609
C[O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[CH2:21][N:22]([C:25]([CH:27]2[CH2:29][CH2:28]2)=[O:26])[CH2:23][CH3:24])[CH:10]=1.CO.[OH-].[Na+].Cl>C1COCC1>[CH:27]1([C:25]([N:22]([CH2:21][C:12]2[CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=[CH:16][C:11]=2[C:9]2[CH:10]=[C:5]([CH2:4][C:3]([OH:30])=[O:2])[CH:6]=[N:7][CH:8]=2)[CH2:23][CH3:24])=[O:26])[CH2:29][CH2:28]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 67212307HCID 67212307, Verbindung

Produkt 1

HCID 45138480(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester (0.069 g, 0.16 mmol) was dissolved in THF (1 mL) and MeOH (0.8 mL) and treated with 1N aqueous NaOH (0.5 mL). The reaction was stirred at room temperature for 1 hour. The mixture was neutralized with 1N aqueous HCl and extracted twice with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated to give Compound 8.

Aufarbeitung

  1. extractionextracted twice with CH2Cl2
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0bbe70d1583b4319a8a51bc85945ffb3
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08049015B2

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