Dimethylformamide → methyl 1-methyl-1H-indole-2-carboxylate
Reaktionsgleichung
[CH3:1]I.N1C2[C:6](=[CH:7][CH:8]=CC=2)[CH:5]=[C:4]1[C:12](O)=O.[C:15](=[O:18])([O-])[O-:16].[K+].[K+].[CH3:21][N:22]([CH3:25])[CH:23]=O>>[CH3:21][N:22]1[C:25]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:12]=[C:23]1[C:15]([O:16][CH3:1])=[O:18]Komponenten
5
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
6.0 ml of methyl iodide were added dropwise to a mixture of 5.00 g of indole-2-carboxylic acid, 100 ml of dimethylformamide and 13.0 g of anhydrous potassium carbonate, and the resulting mixture was stirred at 100° C. for 6 hours. At the end of this time, the reaction mixture was worked up following the procedure described in Preparation 5, to give 5.12 g of the title compound, melting at 91.3°-92.8° C.