Glycolic Acid → HCID 178519921, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:10](O)(=O)[CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:10]([CH2:11][OH:12])[NH:8][C:5]2=[N:6][CH:7]=1Komponenten
3
Versuchsvorschrift
A procedure similar to that described in Preparation 43 was repeated, except that 7.00 g of 5-bromo-2,3-diaminopyridine (prepared as described in Preparation 57) and 8.50 g of glycolic acid were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 7.05 g of the title compound, melting at 230°-233° C.
Aufarbeitung
- customA procedure similar to that described in Preparation 43
Quellen und Nachweise
- ORD-Eintrag
- ord-258830a8cec74256ae7bf551b8976fb9
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05624935
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