2-Tert-Butylphenol → 2-(2-Tert-butylphenoxy)-3-nitrothiophene

HRID 555429

Reaktionsgleichung

Reaktionsgleichung von HRID 555429
Cl[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8].[C:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20])([CH3:13])([CH3:12])[CH3:11].C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[C:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8])([CH3:13])([CH3:11])[CH3:12]

Komponenten

5

Edukt 3

HCID 69232-Tert-ButylphenolHCID 11430Potassium CarbonateHCID 2201862-Chloro-3-nitrothiophene

Produkt 1

HCID 598573712-(2-Tert-butylphenoxy)-3-nitrothiophene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
105 °C

Versuchsvorschrift

To a solution of 2-chloro-3-nitrothiophene (1.13 g, 6.93 mmol) in NMP (10 mL) in a pressure vessel was added 2-tert-butylphenol (1.04 g, 6.93 mmol) and K2CO3 (1.0 g, 10.1 mmol). The reaction was flushed with nitrogen, sealed and then heated to 105° C. for 48 h. The reaction was cooled to rt, diluted with EtOAc (˜150 mL) and washed twice with saturated aqueous NaCl (2ט150 mL). The aqueous washes were then back extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated to yield the crude desired product.

Aufarbeitung

  1. customThe reaction was flushed with nitrogen
  2. customsealed
  3. temperatureThe reaction was cooled to rt
  4. additiondiluted with EtOAc (˜150 mL)
  5. washwashed twice with saturated aqueous NaCl (2ט150 mL)
  6. extractionThe aqueous washes were then back extracted with EtOAc
  7. dry with materialThe combined organics were dried over MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-eb9dfcffa5234e0e81072bfdd967b62b
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08053450B2

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