Acetic acid, 2-(4-formylphenoxy)- → 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetic acid, 2-(4-formylphenoxy)-	HCID 89177	—
Edukt	2-Amino-4,6-dimethoxybenzamide	HCID 20349016	—
Edukt	2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one	HCID 136038000	—
Produkt	2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid	HCID 136038018	21%

Reaktionsschritte

2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid was synthesized from 2-amino-4,6-dimethoxy-benzamide and (4-formyl phenoxy)acetic acid, using the method described for 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one. 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid (135 mg, 21%) was isolated as an off-white solid. Selected data: MS (m/z): 357.04; MP 287-290° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08053440B2
Quelldatensatz	uspto-grants-2011_11
ORD ID	ord-0caacbde8dc94d8da7a2cd24dd32c886
Quellennotiz	uspto-grants-2011_11