Hydrochloric Acid → HCID 178433888, Verbindung

Reaktionsgleichung

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21]([C:23]3[S:24][C:25]([C:28]([O:30]C)=[O:29])=[CH:26][CH:27]=3)=[O:22])[CH3:18])[C:13]([CH3:32])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21]([C:23]3[S:24][C:25]([C:28]([OH:30])=[O:29])=[CH:26][CH:27]=3)=[O:22])[CH3:18])[C:13]([CH3:32])=[N:12]2)=[CH:9][CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

Versuchsvorschrift

14.9 mg (0.033 mmol) of 5-methoxycarbonyl-2-thiophenecarboxylic acid N′-(1-(1-(4-tert-butylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide in 1.5 mL of methanol was stirred with 164 μL (0.164 mmol) of 1M aqueous sodium hydroxide at room temperature for 17 hours. After the stirring, 164 μL (0.164 mmol) of 1M hydrochloric acid was added, and the precipitated solid was collected by filtration to obtain 6.8 mg of the desired product as a pale yellow solid (yield 47%).