HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[N-(4-t-butoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile | HCID 11031276 | — |
| Edukt | Tert-butyl 4-aminobicyclo(2.2.2)octane-1-carboxylate | HCID 23149669 | — |
| Produkt | (2S)-1-[[N-(4-t-butoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile | HCID 66987188 | 65,1% |
Reaktionsschritte
In a similar manner to Example 2, t-butyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (100 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (90.0 mg) were used to obtain (2S)-1-[[N-(4-t-butoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (97.6 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08053465B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-4daf744fe9e445d88c19910272f20dee |
| Quellennotiz | uspto-grants-2011_11 |