Potassium Carbonate → [4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

HRID 555730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 555730
[N:1]1([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:15][C:16]#[N:17].C([O-])([O-])=O.[K+].[K+]>CC#N>[N:1]1([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:15][C:16]#[N:17])[CH2:12][CH2:13]2)[CH:5]=[CH:4][N:3]=[CH:2]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 27593491-(2-Imidazol-1-yl-ethyl)-piperazine

Produkt 1

HCID 86641785[4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 1-(2-Imidazol-1-yl-ethyl)-piperazine (commercially available from CHESS GmbH) (1.0 g, 5.44 mmol), bromoacetonitrile (740 mg, 6.0 mmol) and K2CO3 (1.65 g, 12.0 mmol) in CH3CN (15 mL) is stirred at RT. After completion the product is isolated by filtration with Celite and washed with CH3CN and dried under reduced pressure to give the title compound as oil; ES-MS: M+H=220.2: CtRet=1.70.

Aufarbeitung

  1. customAfter completion the product is isolated by filtration with Celite
  2. washwashed with CH3CN
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5e63030a66e846a797aa9808e31403b4
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08053457B2

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