Bromoacetonitrile → (4-Pyridin-2-ylmethyl-piperazin-1-yl)-acetonitrile

HRID 555743

Reaktionsgleichung

Reaktionsgleichung von HRID 555743
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Br[CH2:15][C:16]#[N:17]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10][CH2:9]1

Komponenten

3

Edukt 2

HCID 11534BromoacetonitrileHCID 8087141-[(Pyridin-2-yl)methyl]piperazine

Produkt 1

HCID 60705417(4-Pyridin-2-ylmethyl-piperazin-1-yl)-acetonitrile

Versuchsvorschrift

The title compound is synthesized by coupling of 1-Pyridin-2-ylmethyl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a brown solid; ES-MS: M+=217.2: 1HNMR(DMSO-d6) 8.45 (dd, 1H), 7.75 (td, 1H), 7.40 (d, 1H), 7.25-7.20 (m, 1H), 3.70 (s, 2H), 3.60 (s, 2H), 2.50-2.35 (m, 8H).

Aufarbeitung

  1. customanalogously to the preparation of Intermediate 149.2 as a brown solid

Quellen und Nachweise

ORD-Eintrag
ord-fba3d5edf14e470fb87f1a886cb3ce80
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08053457B2

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