Bromoacetonitrile → [4-(Tetrahydro-furan-2-ylmethyl)-piperazin-1-yl]-acetonitrile

HRID 555749

Reaktionsgleichung

[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Br[CH2:14][C:15]#[N:16]>>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([CH2:14][C:15]#[N:16])[CH2:11][CH2:12]1

Komponenten

Edukt 2

HCID 11534Bromoacetonitrile

HCID 27372651-(Tetrahydro-2-furylmethyl)piperazine

Produkt 1

HCID 55027705[4-(Tetrahydro-furan-2-ylmethyl)-piperazin-1-yl]-acetonitrile

Versuchsvorschrift

The title compound is synthesized by coupling of 1-(Tetrahydro-furan-2-ylmethyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=210.2.

Aufarbeitung

customanalogously to the preparation of Intermediate 149.2 as a white solid

Quellen und Nachweise

ORD-Eintrag: ord-0b66656f762549f08b7de371a7c9b6db
Quelldatensatz: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08053457B2

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