Bromoacetonitrile → (4-Indan-1-yl-piperazin-1-yl)-acetonitrile

Reaktionsgleichung

[CH:1]1([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:17][C:18]#[N:19]>>[CH:1]1([N:10]2[CH2:15][CH2:14][N:13]([CH2:17][C:18]#[N:19])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Komponenten

Edukt 2

HCID 11534Bromoacetonitrile

HCID 108458021-(2,3-dihydro-1H-inden-1-yl)piperazine

Produkt 1

HCID 86641798(4-Indan-1-yl-piperazin-1-yl)-acetonitrile

Versuchsvorschrift

The title compound is synthesized by coupling of 1-Indan-1-yl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=242.2: CtRet=4.25.

Aufarbeitung

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Quellen und Nachweise

ORD-Eintrag: ord-4e927e96c23c49c6ae3fdb6766f989c0
Quelldatensatz: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08053457B2

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