(Diethylamino)sulfur trifluoride → 2-Fluoro-3-(4-fluorotetrahydro-2H-pyran-4-YL)pyrazine

HRID 555859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 555859
[F:1][C:2]1[C:3]([C:8]2(O)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1.CCN(S(F)(F)[F:21])CC>C(Cl)Cl>[F:1][C:2]1[C:3]([C:8]2([F:21])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1

Komponenten

4

Edukt 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 593512304-(3-Fluoropyrazin-2-YL)tetrahydro-2H-pyran-4-OL

Produkt 1

HCID 593511352-Fluoro-3-(4-fluorotetrahydro-2H-pyran-4-YL)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-(3-fluoropyrazin-2-yl)tetrahydro-2H-pyran-4-ol (0.123 g, 0.621 mmol) in DCM (2 mL) cooled to 0° C. was added dropwise dast (0.164 mL, 1.241 mmol). The resulting mixture was stirred for 2 hr. Reaction was quenched with dropwise addition of saturated NaHCO3 solution and back extracted with DCM to produce product.

Aufarbeitung

  1. customReaction
  2. customwas quenched with dropwise addition of saturated NaHCO3 solution
  3. extractionback extracted with DCM
  4. customto produce product

Quellen und Nachweise

ORD-Eintrag
ord-f6d5830ddd86440fa0af1512dadf484c
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08053438B2

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