3-Methoxy-6-methyl-2-nitropyridine → 3-Methoxy-6-methylpyridin-2-amine

HRID 556508

Reaktionsgleichung

Reaktionsgleichung von HRID 556508
[CH3:1][O:2][C:3]1[C:4]([N+:10]([O-])=O)=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1>C(O)C.[C].[Pd]>[NH2:10][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[C:6]([CH3:9])[N:5]=1

Komponenten

4

Edukt 1

HCID 27279653-Methoxy-6-methyl-2-nitropyridine

Produkt 1

HCID 167403823-Methoxy-6-methylpyridin-2-amineAusbeute 91,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 3-methoxy-6-methyl-2-nitropyridine (3.85 g) in ethanol (91.6 ml) was added 10% palladium-carbon (50% wet, 0.96 g), and the mixture was stirred under hydrogen atmosphere for 2 hours. The catalyst was filtered off, and the filtrate was concentrated to dryness. The residue was recrystallized from ethyl acetate/hexane to give the title compound (2.89 g).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was recrystallized from ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-3394ffa521884b1daa0a2b72f8267ce7
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058280B2

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