Cyclohexylamine → HCID 59639572, Verbindung

HRID 556640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 556640
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:12]2[N:13]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:30])[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Komponenten

3

Edukt 2

HCID 7965CyclohexylamineHCID 59639608HCID 59639608, Verbindung

Produkt 1

HCID 59639572HCID 59639572, VerbindungAusbeute 48,1 %

Versuchsvorschrift

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and cyclohexylamine (0.27 mL, 2.36 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 100 mg (48%). LC-MS: 443.4 (MH+, m/z), 2.79 (Rt, min).

Aufarbeitung

  1. customto give the crude material, which
  2. customwas purified

Quellen und Nachweise

ORD-Eintrag
ord-6c70eb76a93945d2a8e7b72054a0834c
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058282B2

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