Propionyl chloride → 2-Ethyl-1-phenyl-1H-quinazolin-4-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2.0 g (9.42 mmol) 2-phenylamino-benzamide were dissolved in 30 ml trichloromethane the solution was cooled to 0° C., and 2.61 g (2.44 ml, 28.2 mmol) propionyl chloride was added slowly. The mixture was boiled for 90 minutes and afterwards neutralized with a saturated sodium bicarbonate solution. After evaporation the substance was crystallized from isopropanol.

Herkunft & Nachweise