Methyl iodide → 6,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

HRID 557129Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 557129
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]([CH3:15])[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:7][C:6]2=[S:22].[I:23][CH3:24]>>[I-:23].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N+:9]([CH3:15])=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:7]=[C:6]2[S:22][CH3:24]

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 866355306,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione

Produkt 1

HCID 669913456,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

Versuchsvorschrift

1.00 g (3.20 mmol) 6,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione was slowly added to 5 ml (80 mmol) iodomethane at 0° C. and stirred for 1 h at room temperature. The solution was filtrated and the residue washed with ethyl ether and dichloromethane.

Aufarbeitung

  1. filtrationThe solution was filtrated
  2. washthe residue washed with ethyl ether and dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-29a46963b21a4491bf07eb420f74de6a
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058431B2

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