HCID 57652073, Verbindung → HCID 57652026, Verbindung

HRID 557707Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 557707
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

Komponenten

4

Edukt 3

HCID 57652073HCID 57652073, VerbindungHCID 66738250HCID 66738250, VerbindungHCID 66738402HCID 66738402, Verbindung

Produkt 1

HCID 57652026HCID 57652026, Verbindung

Versuchsvorschrift

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

Aufarbeitung

  1. customThis material was directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a3058c29bdc249fd8c6b740bbcad3005
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058299B2

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