Ammonia → 3-Cyanobenzamide

HRID 558317

Reaktionsgleichung

Reaktionsgleichung von HRID 558317
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])#[N:3]>ClCCl>[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:1])=[O:8])#[N:3]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 3084833-Cyanobenzoyl chloride

Produkt 1

HCID 769743-Cyanobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

0.88 Ammonia solution (30 ml) was slowly added to a solution of 3-cyanobenzoyl chloride (10 g, 60.3 mmol) in dichloromethane (100 ml) at 0° C. under nitrogen and the reaction was stirred for 20 minutes. The mixture was filtered and the solid was washed with water (50 ml) then diethylether (50 ml), azeotroped with toluene and dried in vacuo to provide the title compound (9 g) as a white solid.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with water (50 ml)
  3. customdiethylether (50 ml), azeotroped with toluene
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f90883a111af416d9a39944da9a1fccb
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063044B2

Verknüpfte Notizen

Wird geladen…