HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 55838Erstellt: 24. Oktober 2026
4-Methylmorpholine → N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide
https://huagongshe.com/de/reaction/55838
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 4-Methylmorpholine | HCID 7972 | — |
| Edukt | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | 3,3,3-Trifluoropropionic acid | HCID 2777972 | — |
| Edukt | 2-((Tert-butyldimethylsilyloxy)methyl)-4-methoxyaniline | HCID 66980081 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide | HCID 66980120 | — |
Reaktionsschritte
A mixture of 2-((tert-butyldimethylsilyloxy) methyl)-4-methoxyaniline (14.0 g), 3,3,3-trifluoro-propionic acid (7.30 g, 57.0 mmol), EDCI (15.0 g, 76.5 mmol), HOBT (11.0 g, 80.2 mmol) and NMM (22 mL, 157 mmol) in anhydrous CH2Cl2 (200 mL) was stirred at 20° C. for 2 hours. The mixture was diluted with CH2Cl2 (100 mL), the organic layer was washed with 1M HCl (100 mL), H2O (100 mL) and brine (100 mL), dried over Na2SO4 and concentrated to give the product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09433618B2 |
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| Quelldatensatz | uspto-grants-2016_09 |
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| ORD ID | ord-773b12b6404c462f850499a2e177f047 |
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| Quellennotiz | uspto-grants-2016_09 |
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