Ethyl 3-formyl-4-methoxybenzoate → 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid

HRID 558421

Reaktionsgleichung

Reaktionsgleichung von HRID 558421
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][C:4]=1/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1.FC(F)(F)C1C=CC(CP(=O)(OCC)OCC)=CC=1.C(C1C=C(C=CC=1OC)C(OCC)=O)=O>>[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:18][CH:17]=1

Komponenten

4

Edukt 3

HCID 638670Ethyl 3-formyl-4-methoxybenzoateHCID 15819199Diethyl 4-(trifluoromethyl)benzylphosphonateHCID 23141481ethyl 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]-benzoate

Produkt 1

HCID 231414894-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid

Versuchsvorschrift

The captioned compound was synthesized from ethyl 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]-benzoate, which had been synthesized from diethyl (4-trifluoromethylbenzyl)phosphonate and ethyl 3-formyl-4-methoxybenzoate obtained in step C of Example 1-2-1, in accordance with the same procedure as in the methods described in step B of Example 2-2-1.

Quellen und Nachweise

ORD-Eintrag
ord-9af344e05e8140a5a4c65a517c7f0d86
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063046B2

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