Triethylamine → HCID 25071457, Verbindung

HRID 558452

Reaktionsgleichung

Reaktionsgleichung von HRID 558452
C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.Cl.Cl.[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][NH:54][CH2:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1.CCN(CC)CC.[CH3:70][O:71][C:72](=[O:78])[CH2:73][CH2:74][C:75](O)=[O:76]>CN(C=O)C.CO>[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][N:54]([CH2:55][C:56]1[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=1)[C:75](=[O:76])[CH2:74][CH2:73][C:72]([O:71][CH3:70])=[O:78]

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 77487monoMethyl succinateHCID 2724699PyBOPHCID 1317292856-Amino-9-[3-(benzylamino)propyl]-2-butoxy-7,9-dihydro-8H-purin-8-one, dihydrochloride

Produkt 1

HCID 25071457HCID 25071457, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

PyBop (0.47 g) was added to a mixture of the product from example 1 step (viii) (0.25 g), Et3N (0.7 ml) and succinic acid monomethyl ester (0.16 g) in DMF (8 ml) and stirred at rt for 4 days. MeOH (10 ml) was added, the solvent evaporated under reduced pressure and the residue purified by RPHPLC, yield 46 mg.

Aufarbeitung

  1. customthe solvent evaporated under reduced pressure
  2. customthe residue purified by RPHPLC, yield 46 mg

Quellen und Nachweise

ORD-Eintrag
ord-01bd19a3c14b44299feb915fed82f286
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063051B2

Verknüpfte Notizen

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