HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | 2,3-Dimethoxyphenol | HCID 78828 | — |
| Edukt | 1,2-Dichloro-4-fluoro-5-nitrobenzene | HCID 533951 | — |
| Edukt | 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)aniline | HCID 66998926 | — |
| Produkt | N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732851 | 62% |
| Produkt | 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene | HCID 66999020 | 65% |
Reaktionsschritte
4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene (1.12 g, 65%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 4,5-dichloro-2-fluoro-1-nitrobenzene (1.05 g, 5.0 mmol) following the general procedure A. This was reduced to 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (0.68 g, 67%) following general procedure B. N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (136 mg, 62%) was prepared from 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (157 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063081B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-edee006339014cad809e5ad870f30ec5 |
| Quellennotiz | uspto-grants-2011_11 |