HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → HCID 59732812, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | Tetrahydropyran-2-methanol | HCID 7524 | — |
| Edukt | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Edukt | 4-Methyl-2-(tetrahydro-2H-pyran-2-ylmethoxy)-phenylamine | HCID 43591698 | — |
| Produkt | HCID 59732812 | HCID 59732812 | 71% |
| Produkt | Tetrahydro-2-[(5-methyl-2-nitrophenoxy)methyl]-2H-pyran | HCID 66999100 | 64% |
Reaktionsschritte
4-Nitro-3-(tetrahydro-pyran-2-ylmethoxy)-toluene (0.80 g, 64%) was prepared from tetrahydropyran-2-ylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (0.50 g, 71%) following general procedure C. 1-[4-Methyl-2-(tetrahydro-pyran-2-ylmethoxy)-phenyl]-3-thiazol-2-yl-urea (246 mg, 71%) was prepared from 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (221 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063081B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-c88374e06c0e4fe39897d46f7154e94d |
| Quellennotiz | uspto-grants-2011_11 |