Phenyltrimethylammonium bromide dibromide → HCID 118071642, Verbindung

HRID 56005Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56005
[Cl:1][C:2]1[C:3]([C:10](=[O:12])[CH3:11])=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[Br-:13].[Br-].[Br-].C[N+](C)(C)C1C=CC=CC=1.C[N+](C1C=CC=CC=1)(C)C.C[N+](C1C=CC=CC=1)(C)C>O1CCCC1>[Br:13][CH2:11][C:10]([C:3]1[C:2]([Cl:1])=[CH:7][C:6]([O:8][CH3:9])=[CH:5][N:4]=1)=[O:12]

Komponenten

4

Edukt 2

HCID 17977687Phenyltrimethylammonium bromide dibromideHCID 838765981-(3-Chloro-5-methoxypyridin-2-yl)ethanone

Produkt 1

HCID 118071642HCID 118071642, VerbindungAusbeute 76,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 0.90 g of 1-(3-chloro-5-methoxypyridin-2-yl)ethanone in 10 ml of tetrahydrofuran, 1.82 g of trimethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the precipitated solid was filtered off, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 1:9 to 3:7) as the eluent to obtain 0.57 g of the desired product as pale yellow crystals.

Aufarbeitung

  1. customAfter completion of the reaction
  2. filtrationthe precipitated solid was filtered off
  3. customthe solvent was evaporated under reduced pressure
  4. customThe resulting residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-41bd32319c9141c3a2e89490c2af54d8
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434684B2

Notizen zur Reaktion

Wird geladen…