HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 3-[3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-4-yl]-propionic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 4-(2-Carboxyethyl)benzeneboronic acid | HCID 3863484 | — |
| Edukt | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one | HCID 67001148 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 3-[3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-4-yl]-propionic acid | HCID 44547744 | — |
Reaktionsschritte
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one (example 5, step 2) was reacted with 4-(2-carboxyethyl)benzeneboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3-[3′-(1-benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-4-yl]-propionic acid as an off-white solid. MS: 525.1 ([M−H]−)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063088B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-612cf48a910b4f8b9c382bbe84c5083e |
| Quellennotiz | uspto-grants-2011_11 |