HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Nitrophenylboronic Acid → 1-Benzenesulfonyl-3-isopropyl-4-(3'-nitro-biphenyl-3-yl)-imidazolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Nitrophenylboronic Acid | HCID 1677 | — |
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 1-Benzenesulfonyl-3-isopropyl-4-(3'-nitro-biphenyl-3-yl)-imidazolidin-2-one | HCID 44548208 | — |
Reaktionsschritte
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with (3-nitrophenyl)boronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-3-isopropyl-4-(3′-nitro-biphenyl-3-yl)-imidazolidin-2-one as a light yellow oil. MS: 466.0 ([M+H]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063088B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-47cc1aa700f8488fa26340982070fbbc |
| Quellennotiz | uspto-grants-2011_11 |