HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 1-Benzenesulfonyl-4-(5'-ethoxy-2'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 5-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 16217468 | — |
| Edukt | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 1-Benzenesulfonyl-4-(5'-ethoxy-2'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one | HCID 44548393 | — |
Reaktionsschritte
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 5-ethoxy-2-fluorophenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(5′-ethoxy-2′-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one as a light yellow oil. MS: 483.2 ([M+H]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063088B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-dad9898def3346c8a0439643f885f996 |
| Quellennotiz | uspto-grants-2011_11 |