Allyl bromide → 3-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

HRID 560316Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 560316
C([O-])([O-])=O.[K+].[K+].Br[CH2:8][CH:9]=[CH2:10].[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([OH:22])[CH:16]=1)[CH3:12]>CC(C)=O>[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([O:22][CH2:10][CH:9]=[CH2:8])[CH:16]=1)[CH3:12]

Komponenten

5

Edukt 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 18007712Ethyl 4-fluoro-3-hydroxybenzoate

Produkt 1

HCID 669987353-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

K2CO3 (96.9 mmol) and 3-bromo-1-propen (64.6 mmol) are added to a solution of 4-fluoro-3-hydroxy-benzoic acid ethyl ester (32.3 mmol) in acetone (50 mL). The mixture is heated to reflux for 16 h, filtered and cooled to RT. The solvents are removed in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.01 min; [M+CH3CN+H]+=266.0.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 16 h
  3. filtrationfiltered
  4. customThe solvents are removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b0f29086079d4af2aca10cfe0353505d
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063099B2

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