1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 58031402, Verbindung

HRID 560694

Reaktionsgleichung

Reaktionsgleichung von HRID 560694
FC(F)(F)C1C=CC(CBr)=CC=1.Br[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:24]=1[N:23]=[CH:22][CH:21]=[CH:20]2.[CH3:25][C:26]1[N:27]=[C:28]([N:36]2[CH2:40][CH2:39][NH:38][C:37]2=[O:41])[S:29][C:30]=1[C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH3:25][C:26]1[N:27]=[C:28]([N:36]2[CH2:40][CH2:39][N:38]([CH2:14][C:15]3[CH:16]=[CH:17][CH:18]=[C:19]4[C:24]=3[N:23]=[CH:22][CH:21]=[CH:20]4)[C:37]2=[O:41])[S:29][C:30]=1[C:31]([O:33][CH2:34][CH3:35])=[O:32]

Komponenten

4

Edukt 3

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 3469148-(Bromomethyl)quinolineHCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Produkt 1

HCID 58031402HCID 58031402, VerbindungAusbeute 82 %

Versuchsvorschrift

Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 8-(bromomethyl)quinoline to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 82% yield: MS (ES+) m/z 397.3 (M+1)

Quellen und Nachweise

ORD-Eintrag
ord-bf5e068c7ad54edfa8e1307d9c90608b
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063084B2

Verknüpfte Notizen

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