Diethylamine → N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamine

HRID 56078Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56078
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10].[CH2:11]([NH:13][CH2:14][CH3:15])[CH3:12]>CCO>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10])[CH2:14][CH3:15])[CH3:12]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene

Produkt 1

HCID 90022808N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamineAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-(bromomethyl)-2-fluoro-4-iodobenzene (1.89 g, 6.0 mmol) and a solution of diethylamine (2.19 g, 30 mmol) in EtOH (60 mL) was stirred at rt overnight under N2, then concentrated in vacuo. The residue was dissolved in EtOAc (100 mL), and washed with water (100 mL×3) followed by brine (100 mL). The organic phase was concentrated in vacuo to give the title compound as colorless oil (1.72 g, 94%).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in EtOAc (100 mL)
  3. washwashed with water (100 mL×3)
  4. concentrationThe organic phase was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-09eac039fcb240d299595f50e5735ec9
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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