Ethyl Bromide → 2-(4-Ethoxyphenyl)thiazole

HRID 56085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56085
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][CH3:21]>CC(C)=O>[CH2:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:6][CH:7]=1)[CH3:21]

Komponenten

5

Edukt 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 2238404-(1,3-Thiazol-2-yl)phenol

Produkt 1

HCID 691606082-(4-Ethoxyphenyl)thiazoleAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a mixture of 2-(4-hydroxyphenyl)thiazole (21.27 g, 0.12 mol) and K2CO3 (82.93 g, 0.60 mol) in acetone (1000 mL) was added bromoethane (39.24 g, 0.36 mol) with stirring at rt. The reaction mixture was heated at 60° C. for 11 h, then cooled to rt, filtered and concentrated in vacuo to give the title compound as a white solid (24.54 g, 100%).

Aufarbeitung

  1. temperatureThe reaction mixture was heated at 60° C. for 11 h
  2. temperaturecooled to rt
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1ffa6d2b914f46358351db5fa944536d
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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