p-Toluenesulfonic acid → 4-(4-(Thiazol-2-yl)phenyl)morpholine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4-morpholinobenzothioamide (2.22 g, 10 mmol) in EtOH (50 mL) were added 2-bromo-1,1-dimethoxyethane (1.69 g, 10 mmol) and p-toluenesulfonic acid (1.90 g, 10 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and filtered. The filter cake was dried to give the title compound as a yellow solid (2.00 g, 81%).

Herkunft & Nachweise