HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)-
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Edukt | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Edukt | HCID 178418630 | HCID 178418630 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- | HCID 23255822 | — |
Reaktionsschritte
The title compound was prepared starting from 1.50 g (7.97 mmol) of 4′-(trifluoromethyl)acetophenone and 31.9 ml (15.95 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.27 g (69% of theory) of the title compound were obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063234B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-66427df2611d405f8128625bf62943a8 |
| Quellennotiz | uspto-grants-2011_11 |