3-(5,7-Difluoro-4-methyl-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole → 3-(4-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561644Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561644
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([C:16]2(O)[C:25]3[C:20](=[CH:21][C:22]([F:27])=[CH:23][C:24]=3[F:26])[O:19][CH2:18][CH2:17]2)[CH2:15][CH2:14]1.FC1C=C(F)C=C2C=1C(C1C3C(=C(CSC)C=CC=3)NC=1)(C)CCO2>>[CH:13]1([C:16]2([C:9]3[C:8]4[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=4)[NH:11][CH:10]=3)[C:25]3[C:20](=[CH:21][C:22]([F:27])=[CH:23][C:24]=3[F:26])[O:19][CH2:18][CH2:17]2)[CH2:14][CH2:15]1

Komponenten

4

Edukt 3

HCID 583920983-(5,7-Difluoro-4-methyl-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583922924-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-ol

Produkt 1

HCID 583921713-(4-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 450 mg (2.54 mmol) of the compound from Example 8A and 574 mg (2.54 mmol) of the compound from Example 172A in analogy to the synthesis of the compound from Example 193. 80 mg (8% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom80 mg (8% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-5aebe192bdfc467c843180fbde78fde3
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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