3-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561648
[S:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)(C3CC3)C)=CC=2[CH:3]=[CH:2]1.Cl[C:28]1[CH:33]=[CH:32][C:31]([C:34]([C:39]2[C:47]3[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=3)[NH:41][CH:40]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:35])=[CH:30][CH:29]=1>>[S:1]1[C:28]2[CH:29]=[CH:30][C:31]([C:34]([C:39]3[C:47]4[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=4)[NH:41][CH:40]=3)([CH:36]3[CH2:37][CH2:38]3)[CH3:35])=[CH:32][C:33]=2[CH:3]=[CH:2]1

Komponenten

3

Edukt 2

HCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583924583-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583921893-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 237 mg (0.63 mmol) of the compound from Example 187 in analogy to the synthesis of the compound from Example 209. 144 mg (56% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom144 mg (56% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-5181c7d0b7b241b592275897dd7b99ac
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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