3-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561649
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=C[C:9]3[O:10]CC[O:13][C:8]=3C=2)C)CC1.Cl[C:29]1[CH:34]=[CH:33][C:32]([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([CH:37]2[CH2:39][CH2:38]2)[CH3:36])=[CH:31][CH:30]=1>>[CH:37]1([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([C:32]2[CH:33]=[CH:34][C:29]3[O:10][CH2:9][CH2:8][O:13][C:30]=3[CH:31]=2)[CH3:36])[CH2:39][CH2:38]1

Komponenten

3

Edukt 2

HCID 445953853-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Produkt 1

HCID 583923733-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 94 mg (0.25 mmol) of the compound from Example 188 in analogy to the synthesis of the compound from Example 209. 56 mg (55% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom56 mg (55% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-15ff84dfa1be4cf88d07f4f83287b4f4
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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