3-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561650
[O:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)(C3CC3)C)=CC=2[O:3][CH2:2]1.Cl[C:28]1[CH:33]=[CH:32][C:31]([C:34]([C:39]2[C:47]3[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=3)[NH:41][CH:40]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:35])=[CH:30][CH:29]=1>>[O:1]1[C:28]2[CH:33]=[CH:32][C:31]([C:34]([C:39]3[C:47]4[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=4)[NH:41][CH:40]=3)([CH:36]3[CH2:38][CH2:37]3)[CH3:35])=[CH:30][C:29]=2[O:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 583921043-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Produkt 1

HCID 583922823-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 214 mg (0.59 mmol) of the compound from Example 189 in analogy to the synthesis of the compound from Example 209. 162 mg (69% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom162 mg (69% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-8026c0c1fd734c929e5196defa23c90d
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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