3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole
Reaktionsgleichung
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC3[O:10][C:11]([F:14])([F:13])[O:12]C=3C=2)C)CC1.Cl[C:30]1[CH:35]=[CH:34][C:33]([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([CH:38]2[CH2:40][CH2:39]2)[CH3:37])=[CH:32][CH:31]=1>>[CH:38]1([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([C:33]2[CH:34]=[CH:35][C:30]3[O:10][C:11]([F:14])([F:13])[O:12][C:31]=3[CH:32]=2)[CH3:37])[CH2:40][CH2:39]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared starting from 33 mg (0.08 mmol) of the compound from Example 190 in analogy to the synthesis of the compound from Example 209. 27 mg (76% of theory) of the target compound were obtained.