3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561652Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561652
Cl[C:2]1C=CC(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2CC2)CC)=CC=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH3:34])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH2:34][CH3:2])=[CH:29][CH:28]=1

Komponenten

3

Edukt 2

HCID 583921183-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Produkt 1

HCID 583924303-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 116 mg (0.31 mmol) of the compound from Example 191 in analogy to the synthesis of the compound from Example 209. 98 mg (78% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom98 mg (78% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-f93de2d4e43d4a72b545865e16e0a72f
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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