3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561661
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([CH:16]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=2[Cl:25])O)[CH2:15][CH2:14]1.ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[Cl:25][C:19]1[CH:20]=[C:21]([F:24])[CH:22]=[CH:23][C:18]=1[CH:16]([CH:13]1[CH2:14][CH2:15]1)[C:9]1[C:8]2[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=2)[NH:11][CH:10]=1

Komponenten

4

Edukt 3

HCID 583921383-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583924042-Chloro-alpha-cyclopropyl-4-fluorobenzenemethanol

Produkt 1

HCID 583924363-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 500 mg (2.82 mmol) of the compound from Example 8A and 566 mg (2.82 mmol) of the compound from Example 155A in analogy to the synthesis of the compound from Example 227. 394 mg (39% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom394 mg (39% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-e8963c43af7f437283b6396afd267c5f
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

Notizen zur Reaktion

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