4-Chloro-alpha-cyclopropylbenzenemethanol → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561666Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561666
[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH:14]1([CH:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)O)[CH2:16][CH2:15]1.ClC1C=C(F)C=CC=1C(C1CC1)C1C2C(=C(CSC)C(F)=CC=2)NC=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([CH:17]([CH:14]2[CH2:15][CH2:16]2)[C:6]2[C:5]3[C:9](=[C:10]([CH2:11][S:12][CH3:13])[C:2]([F:1])=[CH:3][CH:4]=3)[NH:8][CH:7]=2)=[CH:20][CH:21]=1

Komponenten

4

Edukt 3

HCID 866794-Chloro-alpha-cyclopropylbenzenemethanolHCID 583922596-Fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583924123-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583923763-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 9A and 468 mg (2.56 mmol) of the compound from Example 153A in analogy to the synthesis of the compound from Example 233. 411 mg (44% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom411 mg (44% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-2239be35a4a0473888e3f35ed2732490
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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