3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

HRID 561671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561671
[CH:1]1([CH:4]([C:17]2[CH:27]=[CH:26][C:20]3[O:21][C:22]([F:25])([F:24])[O:23][C:19]=3[CH:18]=2)[C:5]2[C:13]3[C:8](=[C:9]([CH2:14][S:15][CH3:16])[CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)[CH2:3][CH2:2]1.ClC1C=CC(C(C2CC2)C2C3C(=C(CS(C)=[O:47])C=CC=3)NC=2)=CC=1>>[CH:1]1([CH:4]([C:17]2[CH:27]=[CH:26][C:20]3[O:21][C:22]([F:25])([F:24])[O:23][C:19]=3[CH:18]=2)[C:5]2[C:13]3[C:8](=[C:9]([CH2:14][S:15]([CH3:16])=[O:47])[CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)[CH2:2][CH2:3]1

Komponenten

3

Edukt 2

HCID 583922543-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indoleHCID 583923293-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583922843-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 100 mg (0.26 mmol) of the compound from Example 231 in analogy to the synthesis of the compound from Example 235. 92 mg (88% of theory) of the target compound were obtained as mixture of diastereomers.

Aufarbeitung

  1. custom92 mg (88% of theory) of the target compound were obtained as mixture of diastereomers

Quellen und Nachweise

ORD-Eintrag
ord-f98ad73fb1914f86887cc4857a33f453
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

Notizen zur Reaktion

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